HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,3,6-Trifluorobenzyl bromide | HCID 519061 | — |
| Reactant | 1-(4-fluorophenyl)-2-(tritylthio)-1H-imidazole-5-carboxylic acid | HCID 71117468 | — |
| Reactant | 1-(4-Fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide | HCID 86677541 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Ethyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylate | HCID 71117421 | — |
Reaction Steps
Ethyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylate (10) was prepared in a similar manner as that described for the synthesis of compound 9 using ethyl 1-(4-fluorophenyl)-2-mercapto-1H-imidazole-5-carboxylate (6) (202 mg, 0.76 mmol), 2,3,6-trifluorobenzyl bromide (0.1 mL, 0.76 mmol), and potassium carbonate (125.9 mg, 0.91 mmol) in acetone (3 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a3d1082ed82d44c696bdcce801d97a5d |
| Source note | uspto-grants-2014_04 |