Dichloromethane → HCID 86677548, compound

Participants

Reaction Steps

A mixture of 2,3,6-trifluoro-N-(4-fluorophenyl)benzimidamide (25) (0.98 mg, 3.65 mmol), (E)-2-bromo-3-isopropoxyacrylaldehyde (1.1 g, 5.48 mmol), and potassium carbonate (0.76 g, 5.48 mmol) in chloroform (7 mL) and water (1 mL) was stirred at room temperature overnight. Dichloromethane and water were added and the layers were separated. The aqueous layer was extracted with dichloromethane and the combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (0-40% EtOAc in hexanes) to afford 1-(4-fluorophenyl)-2-(2,3,6-trifluorophenyl)-1H-imidazole-5-carbaldehyde (26).

Provenance & Evidence