HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminumhydride → 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | 1-(4-Fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide | HCID 86677541 | — |
| Reactant | HCID 178519842 | HCID 178519842 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde | HCID 86677550 | — |
Reaction Steps
1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde (32) was prepared in a similar manner as that described for the synthesis of compound 12 using 1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide (9) (1.15 g, 2.7 mmol), diisobutyl aluminum hydride (DiBAL) (1M in THF, 5.5 mL, 5.5 mmol), and THF (5 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-df16d8664b4e4316a70296a325a119d4 |
| Source note | uspto-grants-2014_04 |