Acetic Acid → HCID 86677552, compound

Participants

Reaction Steps

A solution of N-(4-fluorophenyl)-2,2-dimethyl-3-(2,3,6-trifluorophenyl) propanimidamide (35) (72.8 mg, 0.22 mmol), acetic acid (14 μL, 0.24 mmol), triethylamine (33 μL, 0.24 mmol), and bromomalonaldehyde (33.9 mg, 0.22 mmol) in isopropyl alcohol (1 mL) was refluxed for 4 h. The reaction was concentrated in vacuo, dichloromethane was added and washed with water. The aqueous phase was extracted with dichloromethane and the combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (0-30% EtOAc in hexanes) to afford 1-(4-fluorophenyl)-2-(2-methyl-1-(2,3,6-trifluorophenyl)propan-2-yl)-1H-imidazole-5-carbaldehyde (36).

Provenance & Evidence