2-Methyl-2-butene → HCID 71117805, compound

Participants

Reaction Steps

1-(4-fluorophenyl)-2-(2-methyl-1-(2,3,6-trifluorophenyl)propan-2-yl)-1H-imidazole-5-carboxylic acid (37) was prepared in a similar manner as that described for the synthesis of compound 27 using 1-(4-fluorophenyl)-2-(2-methyl-1-(2,3,6-trifluorophenyl)propan-2-yl)-1H-imidazole-5-carbaldehyde (36) (59.2 mg, 0.16 mmol), 2-methyl-2-butene (2M in THF, 0.53 mL, 1.05 mmol), sodium chlorite (80%, 59.6 mg, 1.6 mmol), sodium phosphate mono-basic (14.7 mg, 0.12 mmol), tert-butanol (1.6 mL), and water (0.8 mL).

Provenance & Evidence