Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Thiosulfate → ethyl 1-(4-fluorophenyl)-2-iodo-1H-imidazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Thiosulfate | HCID 24477 | — |
| 반응물 | N-Iodosuccinimide | HCID 120273 | — |
| 반응물 | Ethyl 1-(4-fluorophenyl)imidazole-5-carboxylate | HCID 55563221 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | ethyl 1-(4-fluorophenyl)-2-iodo-1H-imidazole-5-carboxylate | HCID 71117744 | — |
반응 단계
A solution of ethyl 1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (14) (5 g, 21.4 mmol), N-iodosuccinimide (12 g, 53.4 mmol), and THF (100 mL) was refluxed overnight. A solution of saturated sodium thiosulfate was added and the reaction was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (0-100% EtOAc in hexanes) to give ethyl 1-(4-fluorophenyl)-2-iodo-1H-imidazole-5-carboxylate (38).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08703776B2 |
| 출처 데이터셋 | uspto-grants-2014_04 |
| ORD ID | ord-a60408fff8234c38825626e3cfffd07a |
| 출처 메모 | uspto-grants-2014_04 |