HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-((2-Chloro-6-fluorophenyl)ethynyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | ethyl 2-((2-chloro-6-fluorophenyl)ethynyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate | HCID 71119630 | — |
| Reactant | N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-mercapto-N-methyl-1H-imidazole-5-carboxamide | HCID 178434002 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-((2-Chloro-6-fluorophenyl)ethynyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid | HCID 71117577 | — |
Reaction Steps
2-((2-Chloro-6-fluorophenyl)ethynyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid (43) was prepared in a similar manner as that described for the synthesis of compound 7 using ethyl 2-((2-chloro-6-fluorophenyl)ethynyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (42) (44 mg, 0.11 mmol), lithium hydroxide (11 mg, 0.46 mmol), THF (0.1 mL), methanol (0.2 mL), and water (0.4 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-207b90a891814c2fbbe57666d3cf15eb |
| Source note | uspto-grants-2014_04 |