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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368508Generated: October 31, 2026

Lithium Hydroxide → HCID 71117831, compound

https://huagongshe.com/reaction/2368508

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
ReactantTetrahydrofuranHCID 8028—
ReactantHCID 71117658HCID 71117658—
ReactantN-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-mercapto-N-methyl-1H-imidazole-5-carboxamideHCID 178434002—
SolventMethanolHCID 887—
SolventWaterHCID 962—
ProductHCID 71117831HCID 71117831—

Reaction Steps

1-(4-Fluorophenyl)-2-(2-(trifluoromethyl)phenethyl)-1H-imidazole-5-carboxylic acid (48) was prepared in a similar manner as that described for the synthesis of compound 7 using ethyl 1-(4-fluorophenyl)-2-(2-(trifluoromethyl)phenethyl)-1H-imidazole-5-carboxylate (47), lithium hydroxide, THF, methanol, and water.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08703776B2
Source datasetuspto-grants-2014_04
ORD IDord-77636027317644e5a166304a4a696164
Source noteuspto-grants-2014_04