HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → HCID 178466974, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 3-Chloro-2,4-pentanedione | HCID 74328 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | HCID 178469260 | HCID 178469260 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178466974 | HCID 178466974 | — |
Reaction Steps
1-(1-(4-Fluorophenyl)-2-mercapto-4-methyl-1H-imidazol-5-yl)ethanone (60) was prepared in a similar manner as that described for the synthesis of compound 57 using 4-fluoroaniline (2 g, 18 mmol), 3-chloropentane-2,4-dione (2.7 g, 19.8 mmol), potassium thiocyanate (3.5 g, 36 mmol) and acetic acid (10 mL) in acetonitrile (100 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-cc6532f8fcd74d3f9335fc51257a3111 |
| Source note | uspto-grants-2014_04 |