Hydroquinone → N-Cyano-N'-propargyl-N"-(2-mercaptoethyl)guanidine

Participants

Reaction Steps

A mixture of 1.136 g (10 m moles) of cysteamine hydrochloride, 1.53 g (10 m moles) of the product of step A, above, and 0.055 g of hydroquinone in 10 ml DMF was slightly warmed to dissolve. To this solution was added 10 ml of 1 N aqueous sodium hydroxide and nitrogen was bubbled through the solution. After standing at room temperature for 17 hours, the reaction mixture was evaporated to dryness to give a mixture of the title product and sodium chloride. The title product was extracted from this mixture with 10 ml of ethanol and the ethanolic solution was used in step C, below.

Provenance & Evidence