Trifluoroacetic acid → HCID 71117564, compound

Participants

Reaction Steps

To a solution of methyl 1-(4-fluorophenyl)-2-(tritylamino)-1H-imidazole-5-carboxylate (66) (200 mg, 0.419 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (5 mL). The reaction was stirred at room temperature overnight, concentrated and the residue was dissolved in ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered, and concentrated and in vacuo to afford methyl 2-amino-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (67) as a yellow solid.

Provenance & Evidence