HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylic acid → Methyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylic acid | HCID 71117327 | — |
| Reactant | 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylate | HCID 86677556 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid | HCID 71117800 | — |
Reaction Steps
Methyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylic acid (69) was prepared in a similar manner as that described for the synthesis of compound 11 using 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxylate (68) (60 mg, 0.158 mmol), 1NLiOH (5 mL) in THF (5 mL) and MeOH (5 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-c336bdd9932c49fd9c05a3b835f6ea10 |
| Source note | uspto-grants-2014_04 |