HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-(((2,6-Dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | ethyl 2-(((2,6-dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate | HCID 71117764 | — |
| Reactant | N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-mercapto-N-methyl-1H-imidazole-5-carboxamide | HCID 178434002 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(((2,6-Dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid | HCID 71117375 | — |
Reaction Steps
2-(((2,6-Dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid (73) was prepared in a similar manner as that described for the synthesis of compound 7 using ethyl 2-(((2,6-dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (72) (1.5 g, 3.5 mmol), lithium hydroxide (1.6 g, 40 mmol), THF (50 mL), methanol (50 mL), and water (20 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703776B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-6d14e2e0a4c04b47a3d3acf94cf44521 |
| Source note | uspto-grants-2014_04 |