4-Fluorophenyl isothiocyanate → HCID 86677560, compound

Participants

Reaction Steps

A mixture of 2-hydrazinyl-N-methyl-2-oxo-N-(pyridin-4-ylmethyl)acetamide (78) (0.96 g, 4.61 mmol) and 4-fluorophenyl isothiocyanate (0.71 g, 4.16 mmol) in EtOH was refluxed for 2 h. The reaction was cooled down to room temperature and concentrated in vacuo to afford 2-(2-((4-fluorophenyl)carbamothioyl)hydrazinyl)-N-methyl-2-oxo-N-(pyridin-4-ylmethyl)acetamide (79) as yellow crystals was obtained in a quantitative yield.

Provenance & Evidence