Hydrochloric Acid → Nilotinib Hydrochloride Anhydrous

Participants

Reaction Conditions

Reaction Steps

Nilotinib (3 gm) was suspended in 2-methyl-2-butanol (120 ml) and then heated to 70° C. A solution of hydrochloric acid in ethyl acetate (4 ml) was added to the solution at 70° C. The solution was stirred for 30 minutes at 70° C. and then cooled to room temperature. The contents were further cooled to 10° C. and maintained for 1 hour at 10° C. The solid obtained was collected by filtration and dried to obtain 3 gm of nilotinib hydrochloride crystalline form H1.

Provenance & Evidence