HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368544Generated: October 31, 2026
Acetic Acid → 6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
https://huagongshe.com/reaction/2368544
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Urea, 1-pentyl-2-thio- | HCID 6451284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one | HCID 57600184 | 65.5% |
Reaction Steps
N-Pentylthiourea (10.0 g, 0.068 mol) was mixed with ethyl cyanoacetate (9.3 g, 0.082 mol) and sodium ethoxide (6.4 g, 0.094 mol) in ethanol (60 mL). The mixture was stirred at 75° C. overnight. After cooling, a solution of 10% acetic acid in water (150 mL) was added. The solid formed was collected by filtration and washed with water to afford the desired product (9.5 g, 65% yield). LCMS calculated for C9H16N3OS: (M+H) 214.1. Found 214.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08703783B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-c9e1f289d6714e0aa816f517c325f793 |
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| Source note | uspto-grants-2014_04 |
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