Ethylorthoformate → HCID 57600223, compound

HRID 2368564Notes

Reaction equation

HRID 2368564 reaction equation
[CH2:1]([N:5]1[C:13]2[N:12]=[CH:11][NH:10][C:9]=2[C:8](=[O:14])[NH:7]/[C:6]/1=[N:15]\[NH2:16])[CH2:2][CH2:3][CH3:4].[CH:17]([O-])([O-])OCC>>[CH2:1]([N:5]1[C:13]2[N:12]=[CH:11][NH:10][C:9]=2[C:8](=[O:14])[N:7]2[CH:17]=[N:16][N:15]=[C:6]12)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 53630039EthylorthoformateHCID 178448643HCID 178448643, compound

Product 1

HCID 57600223HCID 57600223, compoundYield 71.8%

Conditions

Temperature
100 °C

Procedure

The mixture of (2E)-3-butyl-3,7-dihydro-1H-purine-2,6-dione 2-hydrazone (200 mg, 0.0009 mol) in Ethyl orthoformate (5 mL, 0.03 mol) was heated at 100° C. overnight. After cooling to room temperature, the reaction mixture was filtrated and dried to give the desired product (150 mg, 71.8%). LCMS calculated for C10H13N6O (M+H): 233.1. Found: 233.1.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe reaction mixture was filtrated
  3. customdried

Sources & evidence

ORD record
ord-285c5476fd7e483d8db836bad0843b67
Source dataset
uspto-grants-2014_04
Patent number
US08703783B2

Reaction notes

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