反应详情

温度

70 °C

The mixture of N-(5-amino-6-oxo-3-pentyl-2-thioxo-1,2,3,6-tetrahydropyrimidin-4-yl)cyclobutanecarboxamide (720 mg, 2.3 mmol) and 2.5 M of sodium hydroxide in water (25 mL) and methanol (25 mL) was stirred at 70° C. for 1 hour. After cooling to room temperature, The reaction mixture was concentrated to remove methanol and then acidified to pH=5. The precipitate formed was filtered and dried to yield the desired product (500 mg, 73.7%). LCMS calculated for C14H21N4OS (M+H): 293.1. Found: 293.1.

1. temperatureAfter cooling to room temperature
2. concentrationThe reaction mixture was concentrated
3. customto remove methanol
4. customThe precipitate formed
5. filtrationwas filtered
6. customdried