HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 9-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 178446164 | HCID 178446164 | — |
| Product | 9-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one | HCID 57600302 | 60.2% |
Reaction Steps
The mixture of (2E)-3-pentyl-3,7-dihydro-1H-purine-2,6-dione 2-hydrazone (200 mg, 0.85 mol) in trifluoroacetic acid (10 mL) was refluxed overnight. The reaction mixture was concentrated and purified by preparative LCMS to yield the desired product (160 mg, 60.2%). LCMS calculated for C12H14F3N6O (M+H): 315.1. Found 315.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703783B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-d2c66ad111134096a752334011c9606a |
| Source note | uspto-grants-2014_04 |