Ammonia hydroxide → 2-amino-3-pentyl-3,7-dihydro-6H-purin-6-one

HRID 2368612Notes

Reaction equation

HRID 2368612 reaction equation
CS[C:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:17])[N:4]=1.[OH-].[NH3:19]>>[NH2:19][C:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:17])[N:4]=1

Participants

3

Reactant 2

HCID 21862953Ammonia hydroxideHCID 576002282-(methylthio)-3-pentyl-3,7-dihydro-6H-purin-6-one

Product 1

HCID 576003172-amino-3-pentyl-3,7-dihydro-6H-purin-6-oneYield 68%

Conditions

Temperature
100 °C

Procedure

2-(Methylthio)-3-pentyl-3,7-dihydro-6H-purin-6-one (5.0 g, 0.020 mol) was mixed with 100 ml of 28% ammonia hydroxide in a seal tube. The mixture was stirred at 100° C. for 4 days. After cooling to room temperature, the solid was filtered and dried to yield the desired product (3.0 g, 68%). LCMS calculated for C10H16N5O (M+H): 222.1. Found: 222.1.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-92390f00e28345339c964165e72a767b
Source dataset
uspto-grants-2014_04
Patent number
US08703783B2

Reaction notes

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