HCID 178446144, compound → HCID 57961335, compound

HRID 2368626Notes

Reaction equation

HRID 2368626 reaction equation
[O:1]=[C:2]1[NH:10]/[C:9](=[N:11]\[N:12]=[CH:13]/[CH2:14][CH2:15][NH:16][C:17](=[O:26])[O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)/[N:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:7]2[N:6]=[CH:5][NH:4][C:3]1=2>C(O)(=O)C>[CH2:19]([O:18][C:17](=[O:26])[NH:16][CH2:15][CH2:14][C:13]1[N:10]2[C:2](=[O:1])[C:3]3[NH:4][CH:5]=[N:6][C:7]=3[N:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:9]2=[N:11][N:12]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 1

HCID 178446144HCID 178446144, compound

Product 1

HCID 57961335HCID 57961335, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of benzyl (3Z)-3-[(2E)-(6-oxo-3-pentyl-1,3,6,7-tetrahydro-2H-purin-2-ylidene)hydrazono]propylcarbamate (4.0 g, 5.6 mol) in acetic acid (50 mLl) was refluxed in the air overnight. The mixture was concentrated and purified by preparative LCMS to give the desired product (1.3 g, 54% yield) as a white solid. LCMS calculated for C21H26N7O3 (M+H): 424.2. Found: 424.2.

Workup

  1. temperaturewas refluxed in the air overnight
  2. concentrationThe mixture was concentrated
  3. custompurified by preparative LCMS

Sources & evidence

ORD record
ord-882280424dc749d49b5e6049f78b1018
Source dataset
uspto-grants-2014_04
Patent number
US08703783B2

Reaction notes

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