Sodium borohydride → HCID 58119742, compound

Participants

Reaction Conditions

Reaction Steps

959 mg (6) Benzyl 4-((5S)-5-(tert-butyldimethylsilyloxy)-2-(1-methoxyethyl)-7,7-dimethyl-3-(4-(trifluoromethyl)benzoyl)-5,6,7,8-tetrahydroquinolin-4-yl)piperidine-1-carboxylate (Example VI (69) are dissolved in 15 ml ethanol. To the mixture 441 mg of sodiumborohydride is added. The reaction is stirred for 2 hours at 70° C. Then 8 equivalents of sodiumborohydride are added and the reaction is stirred over night at 70° C. The solvent is evaporated under vacuum. Water, ethylacetate and 1M hydrochloric acid are added. The aqueous phase is extracted with ethylacetate and the combined organic phases are washed with brine. After drying with natrium sulphate the solvents are evaporated under vacuum and the residue is chromatographed on isolate.

Provenance & Evidence