4-Phenoxyphenylboronic acid → HCID 67234969, compound

HRID 2368716Notes

Reaction equation

HRID 2368716 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH2:5][N:6]1[C:10](=[O:11])[CH:9]2[CH:12]=[C:13](Br)[S:14][CH:8]2[C:7]1=[O:16])[CH3:2].[O:18]([C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][N:6]1[C:10](=[O:11])[CH:9]2[CH:12]=[C:13]([C:28]3[CH:29]=[CH:30][C:25]([O:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:26][CH:27]=3)[S:14][CH:8]2[C:7]1=[O:16])[CH3:2]

Participants

3

Reactant 2

HCID 27343774-Phenoxyphenylboronic acidHCID 67232936HCID 67232936, compound

Product 1

HCID 67234969HCID 67234969, compound

Procedure

The title compound was prepared from (2-bromo-4,6-dioxo-3a,4,6,6a-tetrahydro-thieno[2,3-c]pyrrol-5-yl)-acetic acid ethyl ester, example 1-d, and 4-phenoxy-phenyl boronic acid under conditions analogous to experimental example 3-a. 1H NMR (CDCl3, 200 MHz): δ=7.58-7.54 (d, J=8.97 Hz, 2H), 7.41-7.34 (m, 3H), 7.20-7.0 (m, 4H), 4.35 (s, 2H), 4.27-4.17 (q, J=7.0, 2H), 1.32-1.25 (t, J=7.0 Hz, 3H).

Sources & evidence

ORD record
ord-f8465cccc9874c9e90811a54d5638750
Source dataset
uspto-grants-2014_04
Patent number
US08703795B2

Reaction notes

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