HCID 86607506, compound → HCID 67233909, compound

HRID 2368718Notes

Reaction equation

HRID 2368718 reaction equation
[CH2:1]([O:5][C:6]([C:8]1[N:13]=[C:12](Br)[C:11]2[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[CH:20][CH:19]=3)[S:17][C:10]=2[C:9]=1[OH:31])=[O:7])[CH2:2][CH2:3][CH3:4].C(OC(C1C(O)=C2C=C(C3C=CC(OC4C=CC=CC=4)=CC=3)SC2=C(Br)N=1)=O)CCC>>[CH2:1]([O:5][C:6]([C:8]1[N:13]=[CH:12][C:11]2[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)=[CH:20][CH:19]=3)[S:17][C:10]=2[C:9]=1[OH:31])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 86607506HCID 86607506, compoundHCID 86607507HCID 86607507, compound

Product 1

HCID 67233909HCID 67233909, compound

Procedure

The title compound was prepared from a mixture of 4-bromo-7-hydroxy-2-(4-phenoxy-phenyl)-thieno[3,2-c]pyridine-6-carboxylic acid butyl ester and 7-bromo-4-hydroxy-2-(4-phenoxy-phenyl)-thieno[2,3-c]pyridine-5-carboxylic acid butyl ester, example 7-c, under conditions analogous to experimental example 13-a with isolation of the higher Rf isomer. MS: (+) m/z 420.03 (M+1).

Sources & evidence

ORD record
ord-919941c32168410b8e64fd77180cfbbf
Source dataset
uspto-grants-2014_04
Patent number
US08703795B2

Reaction notes

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