HCID 67233533, compound → HCID 66861909, compound

HRID 2368741Notes

Reaction equation

HRID 2368741 reaction equation
COC(C1C=C(C2C=CC(F)=CC=2)SC=1C(=O)[NH:18][CH2:19][C:20]([O:22]CC)=[O:21])=O.CO[C:28]([C:30]1[S:31][C:32]([C:44]2[CH:49]=[CH:48][C:47]([F:50])=[CH:46][CH:45]=2)=[CH:33][C:34]=1[C:35](=O)[NH:36][CH2:37][C:38]([O:40]CC)=O)=[O:29]>>[F:50][C:47]1[CH:46]=[CH:45][C:44]([C:32]2[S:31][C:30]3[C:28]([OH:29])=[C:37]([C:38]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:40])[N:36]=[CH:35][C:34]=3[CH:33]=2)=[CH:49][CH:48]=1

Participants

3

Reactant 2

HCID 67233533HCID 67233533, compoundHCID 67233752HCID 67233752, compound

Product 1

HCID 66861909HCID 66861909, compound

Procedure

The title compound was prepared from 2-(ethoxycarbonylmethyl-carbamoyl)-5-(4-fluoro-phenyl)-thiophene-3-carboxylic acid methyl ester and 3-(ethoxycarbonylmethyl-carbamoyl)-5-(4-fluoro-phenyl)-thiophene-2-carboxylic acid methyl ester, example 34-a, under conditions analogous to experimental example 30-f. MS: (+) m/z 362.2 (M+1).

Sources & evidence

ORD record
ord-52011457210d41ab814ee1e860c66a46
Source dataset
uspto-grants-2014_04
Patent number
US08703795B2

Reaction notes

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