HCID 67233208, compound → HCID 11845481, compound

HRID 2368744Notes

Reaction equation

HRID 2368744 reaction equation
C([O:5][C:6]([C:8]1[N:13]=C(Br)C2C=C(C3C=CC(F)=CC=3)SC=2C=1O)=[O:7])CCC.C(OC(C1C(O)=C2C=C(C3C=CC(F)=CC=3)SC2=C(Br)N=1)=O)CCC.C(O[C:56]([C:58]1[N:63]=[C:62]([CH3:64])[C:61]2[CH:65]=[C:66]([C:68]3[CH:73]=[CH:72][C:71]([F:74])=[CH:70][CH:69]=3)[S:67][C:60]=2[C:59]=1[OH:75])=[O:57])CCC.C(OC(C1C(O)=C2C=C(C3C=CC(F)=CC=3)SC2=C(C)N=1)=O)CCC>>[F:74][C:71]1[CH:70]=[CH:69][C:68]([C:66]2[S:67][C:60]3[C:59]([OH:75])=[C:58]([C:56]([NH:13][CH2:8][C:6]([OH:7])=[O:5])=[O:57])[N:63]=[C:62]([CH3:64])[C:61]=3[CH:65]=2)=[CH:73][CH:72]=1

Participants

5

Reactant 4

HCID 67233208HCID 67233208, compoundHCID 67233520HCID 67233520, compoundHCID 86607514HCID 86607514, compoundHCID 86607515HCID 86607515, compound

Product 1

HCID 11845481HCID 11845481, compound

Procedure

The title compound was prepared from 4-bromo-2-(4-fluoro-phenyl)-7-hydroxy-thieno[3,2-c]pyridine-6-carboxylic acid butyl ester and 7-bromo-2-(4-fluoro-phenyl)-4-hydroxy-thieno[2,3-c]pyridine-5-carboxylic acid butyl ester, example 34-c, under conditions analogous to experimental example 32-b. MS for 2-(4-fluoro-phenyl)-7-hydroxy-4-methyl-thieno[3,2-c]pyridine-6-carboxylic acid butyl ester: (+) m/z 360.0.0 (M+1). MS for 2-(4-fluoro-phenyl)-4-hydroxy-7-methyl-thieno[2,3-c]pyridine-5-carboxylic acid butyl ester: (+) m/z 360.0.0 (M+1).

Sources & evidence

ORD record
ord-62ab5ab6599a420db389e85b48abf6ce
Source dataset
uspto-grants-2014_04
Patent number
US08703795B2

Reaction notes

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