反应详情

1-Oxo-2,3-dihydro-1H-inden-5-carbonitrile (7.85 g, 50 mmol) was dissolved in 50 mL of methanol. To it was added sodium borohydride (2.3 g, 60 mmol) gradually within about 30 minutes. The solution was concentrated after being stirred for 2 hours. The residue was dissolved in ethyl acetate and the solution obtained was washed with sodium bicarbonate twice and then with brine twice, dried over magnesium sulfate, filtered, and concentrated to obtain 8 g of the desired compound (100% yield). MS (M+1)=160.07.

1. concentrationThe solution was concentrated
2. dissolutionThe residue was dissolved in ethyl acetate
3. customthe solution obtained
4. washwas washed with sodium bicarbonate twice
5. dry with materialwith brine twice, dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated