反应详情

1-Hydroxy-2,3-dihydro-1H-indene-5-carbonitrile (4.77 g, 30 mmol) was dissolved in 10 mL of methylene dichloride. While cooled on ice, thionyl chloride (6.6 ml, 90 mmol) was added dropwise within about 15 minutes. The solution was concentrated after being stirred for 3 hours. The residue was dissolved in ethyl acetate and the solution obtained was washed with cooled brine for 3 times, dried over anhydrous magnesium sulfate, and concentrated to obtain 1-chloro-2,3-dihydro-1H-indene-5-carbonitrile.

1. additionwas added dropwise within about 15 minutes
2. concentrationThe solution was concentrated
3. dissolutionThe residue was dissolved in ethyl acetate
4. customthe solution obtained
5. washwas washed with cooled brine for 3 times
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated