Sodium Carbonate → HCID 58579019, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-1-chloro-2,3-dihydro-1H-indene (10 g, 43 mmol) was dissolved in 80 mL of acetonitrile, and sodium carbonate (4.8 g, 45 mmol) was added followed by tert-butyl piperazin-1-carboxylate (9.7 g, 52 mmol). The mixture was stirred at 60° C. overnight. The insoluble substance was removed by filtration and the filtrate was concentrated. The residue was separated by silica gel column using ethyl acetate/hexanes (1:2 to 1:1) as the eluent to obtain 12 g (72% yield) of the subtitle compound. MS (M+1)=381.11, 383.11.

Provenance & Evidence