Sodium Hydroxide → HCID 58579021, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 4-[5-(ethoxycarbonyl)-2,3-dihydro-1H-inden-1-yl)piperazin-1-carboxylate (8 g, 21.36 mmol) was dissolved in 20 mL of methanol, and 30 mL of sodium hydroxide (1 N) was added. The solution was stirred overnight at room temperature and at 50° C. for another 2 hours, and then concentrated. The residue was dissolved in water (50 mL) and the obtained solution was acidified to pH 5 with 1 N HCl and then extracted with ethyl acetate (3×100 mL). The extract liquor was pooled together, dried over magnesium sulfate, and concentrated to obtain the subtitle compound. MS (M+1)=347.19.

Provenance & Evidence