HCID 46830969, compound → HCID 46830970, compound

Participants

Reaction Steps

tert-Butyl 4-{5-[({4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino)carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate (2 g, 3.3 mmol) was dissolved in 4 N HCl in dioxane (10 mL). The solution was concentrated to obtain the solid product after being stirred at room temperature for 3 hours. The product (100 mg) was purified by high performance liquid chromatography at pH=10 to obtain the subtitle compound. MS (M+1)=506.26. 1HNMR (DMSO-d6, ppm): δ 10.08 (s, 1H); 9.20 (s, 1H); 8.93 (s, 1H); 8.62 (d, J=4.8 Hz, 1H); 8.44 (d, J=5.2 Hz, 1H); 8.40 (d, J=8.0 Hz, 1H); 8.00 (s, 1H); 7.72 (s, 1H); 7.70 (d, J=8.0 Hz, 1H); 7.45 (dd, J=8.2 Hz, 4.8 Hz, 1H); 7.41 (d, J=8.2 Hz, 1H); 7.36 (d, J=5.2 Hz, 1H); 7.31 (d, J=8.0 Hz, 1H); 7.12 (d, J=8.8 Hz, 1H); 4.22 (t, J=6.8 Hz, 1H); 2.80 (m, 2H); 2.60 (m, 4H); 2.35 (m, 2H); 2.22 (m, 2H); 2.15 (s, 3H); 2.00 (m, 2H).

Provenance & Evidence