Thionyl Chloride → HCID 86660688, compound

Participants

Reaction Steps

SOCl2 (2.5 L) was added to a 5 L three-neck flask. (1S)-1-(4-Methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxylic acid (1289 g, the actual maximum content of 583 g, equivalent to 2.235 mol) was then added in batches within 1 hour. The solution was heated under reflux overnight and then cooled to room temperature. Most of SOCl2 was removed using rotary evaporator. After ethyl acetate (1.5 L) was added, the solution was cooled to 0° C., filtered with suction to obtain the white solid which was then dried in vacuum to get the title compound (about 1325 g, 100% yield).

Provenance & Evidence