HCID 66580148, compound → HCID 66580033, compound

HRID 2368813Notes

Reaction equation

HRID 2368813 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][C@@H:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])=[N:8][CH:9]=1)([O-])=O.[H][H]>[Pd].CO>[F:15][C:12]([F:13])([F:14])[C@H:11]([CH3:16])[O:10][C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 66580148HCID 66580148, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66580033HCID 66580033, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-Nitro-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine (81.9 g) and palladium on carbon (10% Pd, 0.0065 mol-eq) were added to MeOH and the mixture was hydrogenated until uptake of hydrogen was ceasing. The catalyst was removed by filtration and the filtrate was concentrated and further dried in vacuo to provide the title compound as a dark oil. MS (m/e): 207.0 (MH+).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customfurther dried in vacuo

Sources & evidence

ORD record
ord-3e044ade9d754bcd86aa88b56bd4cc29
Source dataset
uspto-grants-2014_04
Patent number
US08703807B2

Reaction notes

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