Benzimidazole → HCID 58284825, compound

Participants

Reaction Conditions

Reaction Steps

Charged Benzimidazole (12.11 mmoles), cesium carbonate (14.11 mmoles), cuprous oxide (0.4 mmoles), 2-Amino-4,6-dihydroxypyrimidine (1.5 mmoles), PEG (catalyst), keto thiophene (XXI) and NMP (5 ml) to the RB flask fitted with thermo well and condenser. The reaction mixture was heated to 155-160° C. and the temperature was maintained for 10-12 hrs at 155-160° C. After completion of reaction, cooled to room temperature, added water (25 ml), extracted with ethyl acetate (2×100 ml), washed with 10% brine solution, dried the ethyl acetate layer over sodium sulfate and distilled off the solvent completely at reduced pressure to get crude compound. The crude compound was purified by using silica gel 60-120 silica gel column chromatography and DCM: methanol: 100-5% as mobile phase to get the pure compound (84).

Provenance & Evidence