Sodium borohydride → HCID 58284857, compound

Participants

Reaction Conditions

Reaction Steps

The compound (84) (0.703 mmoles) was dissolved in methanol (10 ml), cooled to 0-5° C., added sodium borohydride in lots at 0-5° C. in 5 minutes, after completion of addition, the reaction mixture was warmed to 25 to 30° C., stirred for 2.0 hrs. After completion of reaction, quenched the reaction with water (10 ml) and extracted in ethyl acetate (2×100 ml), washed with 10% brine, and dried over sodium sulphate. Distilled off the ethyl acetate completely to residue to get the crude compound, The crude compound was purified by using silica gel 60-120 silica gel column chromatography and DCM: methanol: 100-5% as mobile phase to get the pure compound (85).

Provenance & Evidence