(R)-(-)-2-Amino-1-propanol → HCID 86682887, compound

HRID 2368895Notes

Reaction equation

HRID 2368895 reaction equation
[CH3:1][C@@H:2]([CH2:7][C:8](OC)=O)[C:3](OC)=O.[NH2:12][C@H:13]([CH3:16])[CH2:14][OH:15]>>[CH3:1][C@H:2]1[CH2:7][CH2:8][N:12]([C@H:13]([CH3:16])[CH2:14][OH:15])[CH2:3]1

Participants

3

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 9964174HCID 9964174, compound

Product 1

HCID 86682887HCID 86682887, compound

Procedure

The title compound was synthesized as described in Intermediate 11 using (S)-dimethyl 2-methylsuccinate and (R)-2-aminopropan-1-ol as starting materials. 1H NMR (CDCl3): δ 3.60 (dd, 1H), 3.58 (br s, 1H), 3.40 (dd, 1H), 2.89 (dd, 1H), 2.72 (m, 2H), 2.63 (m, 1H), 2.24 (m, 1H), 2.17 (dd, 1H), 2.00 (m, 1H), 1.35 (m, 1H), 1.04 (m, 6H); MS: 144.3 (M+H)+.

Sources & evidence

ORD record
ord-9314facbeadf427e8ac10bf163d8144d
Source dataset
uspto-grants-2014_04
Patent number
US08703810B2

Reaction notes

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