L-Alaninol → HCID 58743065, compound

HRID 2368897Notes

Reaction equation

HRID 2368897 reaction equation
[CH3:1][C@@H:2]([CH2:7][C:8](OC)=O)[C:3](OC)=O.[NH2:12][C@@H:13]([CH3:16])[CH2:14][OH:15]>>[CH3:1][C@H:2]1[CH2:7][CH2:8][N:12]([C@@H:13]([CH3:16])[CH2:14][OH:15])[CH2:3]1

Participants

3

Reactant 2

HCID 80307L-AlaninolHCID 9964174HCID 9964174, compound

Product 1

HCID 58743065HCID 58743065, compound

Procedure

The title compound was synthesized as described in Intermediate 11 using (S)-dimethyl 2-methylsuccinate and (S)-2-aminopropan-1-ol as starting materials. 1H NMR (CDCl3): δ 3.57 (dd, 1H), 3.32 (dd, 1H), 3.02 (br s, 1H), 2.81 (dd, 1H), 2.69 (m, 2H), 2.60 (m, 1H), 2.21 (m, 1H), 2.12 (dd, 1H), 1.98 (m, 1H), 1.32 (m, 1H), 1.04 (m, 6H); MS: 144.3 (M+H)+.

Sources & evidence

ORD record
ord-b5be13fb2746416c9cb9f7e6face2085
Source dataset
uspto-grants-2014_04
Patent number
US08703810B2

Reaction notes

Loading…