Hydrochloric Acid → HCID 26985459, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-fluoro-5-methoxyphenyl)acetonitrile (2.62 g, 16 mmol) in MeOH:H2O (1:1; 15 mL), NaOH (1.28 g, 32 mmol) was added. Then the mixture was stirred at 65° C. for 4 h. The mixture was cooled to room temperature, and 4M aqueous HCl solution was added until the pH was adjusted to 4-5. The mixture was filtered and the solid obtained was washed with H2O (2×5 mL) to give 2.33 g of 2-(3-fluoro-5-methoxyphenyl)acetic acid. 1H NMR (CDCl3): δ 6.52-6.62 (m, 3H), 3.78 (s, 3H), 3.59 (s, 2H).

Provenance & Evidence