2-Bromoethanol → (2-Bromoethoxy)-tert-butyldimethylsilane

Participants

Reaction Steps

To a mixture of 2-bromo-ethanol (12.5 g, 0.1 mol) and TEA (11.2 g, 0.11 mol) in CH2Cl2 (40 mL), TBSCl (15.8 g, 0.105 mol) and DMAP (0.122 g, 1 mmol) were added. The reaction mixture was stirred at room temperature for 12 h, washed (10 mL 2M HCl, 10 mL H2O), dried (Na2SO4) and concentrated to give the desired product as colorless oil. 1H NMR (CDCl3): δ 3.88 (m, 2H), 3.39 (m, 2H), 0.89 (s, 9H), 0.08 (s, 6H).

Provenance & Evidence