反应详情

温度

60 °C

To a mixture of 2-(2-fluoro-3-methoxyphenyl)acetonitrile (6.7 g, 40.6 mmol) in water (40 mL) and methanol (40 mL), sodium hydroxide (3.2 g, 81.1 mmol) was added. The resulting mixture was stirred at 60° C. for 5 h. After cooling to room temperature, methanol was evaporated under reduced pressure. The residue was acidified with 10% HCl until pH 5. The resulting precipitate was collected by filtration and dried to afford the title compound (6.3 g).

1. additionwas added
2. temperatureAfter cooling to room temperature
3. custommethanol was evaporated under reduced pressure
4. filtrationThe resulting precipitate was collected by filtration
5. customdried