HCID 13777646, compound → HCID 86682910, compound

HRID 2368941Notes

Reaction equation

HRID 2368941 reaction equation
CS(O[C@H:6]([CH3:28])[CH2:7][O:8]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)(=O)=O.Cl.[CH:30]12[NH:36][CH:33]([CH2:34][CH2:35]1)[CH2:32][CH2:31]2>>[CH:33]12[N:36]([C@@H:6]([CH3:28])[CH2:7][OH:8])[CH:30]([CH2:35][CH2:34]1)[CH2:31][CH2:32]2

Participants

3

Reactant 2

HCID 13777646HCID 13777646, compoundHCID 162795037-Azabicyclo[2.2.1]heptane hydrochloride

Product 1

HCID 86682910HCID 86682910, compound

Procedure

The title compound was synthesized as described in Intermediate 39 (steps 2-3) using (R)-1-(trityloxy)propan-2-yl methanesulfonate and 7-azabicyclo[2.2.1]heptane hydrochloride as starting materials. 1H NMR (DMSO-d6): δ 4.36 (t, 1H), 3.42 (m, 3H), 3.07 (m, 1H), 2.26 (m, 1H), 1.54 (m, 4H), 1.18 (m, 4H), 0.96 (d, 3H).

Sources & evidence

ORD record
ord-13b1e7c078034324b1729b02bf47e509
Source dataset
uspto-grants-2014_04
Patent number
US08703810B2

Reaction notes

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