1-Hydroxybenzotriazole → HCID 178516353, compound

Participants

Reaction Steps

A mixture of 5-(8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one (86 mg, 0.19 mmoL), 1H-1,2,4-triazole-3-carboxylic acid (25.9 mg, 0.23 mmoL), EDC (73 mg, 0.38 mmoL), HOBt (51.6 mg, 0.38 mmoL) and DIEA (199 uL, 1.15 mmoL) in DMF (4 mL) was stirred at room temperature for 2 h. Purification with prep-LC provided 5-(8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one: LCMS tR=2.33 Min (10 min run, UV254nm). Mass calculated for, M+ 545.2, observed LC/MS m/z 546.01 (M+H).

Provenance & Evidence