Potassium Carbonate → HCID 59631861, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 3-(5-bromothiophen-2-yl)-1-methyl-1H-pyrazole (0.20 g, 0.83 mmol), 3-methanesulfonyl-phenylboronic acid (0.20 g, 1.0 mmol), K2CO3 (345 mg, 2.5 mmol), Cl2Pd(dppf).DCM (82 mg, 10 mol %) and H2O (0.6 mL) in dioxane (6 mL) was sparged with Argon for 5 min and then heated at 85° C. as a sealed flask. After 6 h the reaction mixture was allowed to cool to ambient temperature, filtered (Celite™) and the filter agent rinsed with EtOAc. The combined filtrates were concentrated under reduced pressure and purified by chromatography (silica, EtOAc/DCM, 2:98 to 5:95) to give the title compound (0.11 g, 42%) as a white solid. 1H-NMR (CD2Cl2): δ 8.15 (1H, m), 7.89 (1H, m), 7.80 (1H, m), 7.60 (1H, m), 7.40 (2H, m), 7.29 (1H, d), 6.50 (1H, d), 3.91 (3H, s), 3.07 (3H, s).

Provenance & Evidence