Potassium Carbonate → HCID 59631704, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[5-(5-bromothiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl]-1,1,1,3,3,3-hexafluoro-propan-2-ol (84 mg, 0.17 mmol), 3-methanesulfonyl-phenylboronic acid (42 mg, 0.21 mmol), K2CO3 (70 mg, 0.51 mmol), Cl2Pd(dppf).DCM (21 mg, 15 mol %) and H2O (0.2 mL) in dioxane (2 mL) was sparged with Argon for 5 min and then heated at 80° C. as a sealed flask. After 3 h the reaction mixture was allowed to cool to ambient temperature, filtered (Celite™) and the filter agent rinsed with EtOAc. The combined filtrates were concentrated under reduced pressure and purified by chromatography (silica, EtOAc/Hex, 0:100 to 50:50) to give the title compound (34 mg) as a white solid. 1H-NMR (DCM-d2): δ 8.03 (m, 1H), 7.83 (m, 1H), 7.76 (m, 1H), 7.55-7.62 (m, 4H), 7.49-7.54 (m, 1H), 7.29 (d, 1H), 6.91 (d, 1H), 6.86 (s, 1H), 5.10 (s, 1H), 3.05 (s, 3H); MS(ES): 581 [M+H]+.

Provenance & Evidence