3-(Methylsulfonyl)phenylboronic acid → HCID 59632458, compound

HRID 2369042Notes

Reaction equation

HRID 2369042 reaction equation
FC(F)(F)S(O[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[N:10]=[C:9]([C:19]([F:22])([F:21])[F:20])[CH:8]=1)(=O)=O.[CH3:25][S:26]([C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1)(=[O:28])=[O:27]>>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[N:11]1[C:7]([C:33]2[CH:32]=[CH:31][CH:30]=[C:29]([S:26]([CH3:25])(=[O:28])=[O:27])[CH:34]=2)=[CH:8][C:9]([C:19]([F:20])([F:21])[F:22])=[N:10]1

Participants

3

Reactant 2

HCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 57470287HCID 57470287, compound

Product 1

HCID 59632458HCID 59632458, compound

Procedure

1-(2-chlorophenyl)-5-[3-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole was prepared in a manner similar to that described in Examples 1c by using 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl trifluoromethanesulfonate and 3-(methylsulfonyl)phenylboronic acid. 1H-NMR (CDCl3): δ 7.90 (1H, m), 7.76 (1H, d), 7.57-7.47 (3H, m), 7.46-7.42 (3H, m), 6.92 (1H, s), 2.92 (3H, s). MS (ES): 401 [M+H]+.

Sources & evidence

ORD record
ord-7b97dce2bb41457e867519819e834021
Source dataset
uspto-grants-2014_04
Patent number
US08703805B2

Reaction notes

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