1-Bromo-2-Chloroethane → HCID 59632103, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazole (2.05 g, 7 mmol) and 1-bromo-2-chloroethane (0.71 mL, 1.2 equiv) in DMF (30 mL) was added NaH (0.42 g, 60%, 1.5 equiv) and the mixture was stirred overnight at 20° C. The reaction was quenched by water. Solid was collected and washed by water and dried under high vacuum to give a crude, which was purified by column chromatography eluting with MeOH-DCM (6:96) to give 5-(4-bromophenyl)-1-(2-chloroethyl)-3-(trifluoromethyl)-1H-pyrazole (400 mg) as a minor product. 1H-NMR (CDCl3): δ 7.64 (d, 1H), 7.31 (d, 1H), 6.54 (s, 1H), 4.41 (t, 2H), 3.93 (t, 2H).

Provenance & Evidence