Hydrochloric Acid → HCID 59633213, compound

Participants

Reaction Steps

(4-{5-[2-(2-Chloro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-thiophen-2-yl}-3-methylphenyl)-acetic acid methyl ester (122 mg, 025 mmol) was dissolved in 6 mL mixture of THF and water (3:1, V/V). Lithium hydroxide monohydrate (23 mg, 0.55 mmol) was then added. After stirring at room temperature for 2 hrs, the mixture was neutralized to pH 7 by 1N HCl, and then extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The crude product was purified by reverse HPLC to give a white solid (66 mg, 55% yield). 1H-NMR (400 MHz, CDCl3): δ 2.33 (s, 3H), 3.65 (s, 2H), 6.88-6.84 (m, 3H), 7.17-7.11 (m, 1H), 7.17 (m, 1H), 7.27 (m, 1H), 7.56-7.42 (m, 4H). MS (ES) 477.2, [M+H]+.

Provenance & Evidence