Lawesson's reagent → HCID 59632628, compound

Participants

Reaction Steps

To a 50 mL round bottom flask attached with condenser was added 5-[5-(3-Methanesulfonyl-phenyl)-thiophen-2-yl]-1-(2-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester (326 mg, 644 μmmol), Lawesson's reagent (520 mg, 129 mmol) and anhydrous toluene (23 mL). The reaction solution was stirred at reflux for 1 day. The reaction solution was concentrated in vacuo, and the crude material was chromatographed through a 25 g SiO2 column using a gradient of 100% Hx to 50% EtOAc to afford 302 mg (90% yield) of the title compound. MS (ES) 523.3 [M+H]+, 545.0 (M+Na)+.

Provenance & Evidence