Methanol → HCID 59632370, compound

Participants

Reaction Steps

To a 100 mL round bottom flask attached with condenser was added 5-[5-(3-Methanesulfonyl-phenyl)-thiophen-2-yl]-1-(2-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (2.52 g, 4.98 mmol), 1N aq NaOH (30 mL), and MeOH (25 mL). The reaction solution was stared at 55° C. for 1.5 hr prior to TLC analysis. The reaction solution was diluted with EtOAc (200 mL), poured into a separately funnel and the organic phase was partitioned. The aqueous phase was neutralized by the addition of aq 1 N HCl and extracted with EtOAc (70 mL×2). The combined organic phase was dried over Na2SO4, filtered into a round bottom flask and concentrated on the Rotavapor. The crude residue was chromatographed thru a 25 g SiO2 column using a mobile phase gradient of 100% Hx to 85% EtOAc to afford 1.35 g (55% yield) title compound. MS (ES) 493.1 [M+H]+.

Provenance & Evidence