Chloroacetonitrile → 1-CyanoMethyl-1,2,3,4-tetrahydro-quinoline

Participants

Reaction Steps

162 parts of 1,2,3,4-tetrahydroquinoline, 126 parts of chloroacetonitrile and 66 parts of sodium carbonate are stirred for 6 hours at a temperature of 105°-115° C. After cooling, the thick brown suspension is diluted with methylene chloride and filtered. After washing thoroughly with methylene chloride, the filtrate is concentrated as far as possible in a water jet vacuum and the residue is subsequently distilled. The main fraction boils at 148°-150° C. at a pressure of 1 torr.

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